You want to consider the genetic diversity of the strain to ensure that it has the potential to adapt to different environmental conditions and resist common pests and diseases. Additionally, consider the reputation and track record of the genetics provider to ensure that you are getting high-quality, reliable genetics.

Look for a supplier that uses a reliable sterilization process to ensure that the grain is free from any unwanted microorganisms. You should also consider the age of the grain spawn, as older spawn may have lower viability and take longer to colonize your substrate. 

First, you should choose a substrate that is compatible with the mushroom species you plan to cultivate. Second, consider the moisture content of the substrate. It’s important to choose a substrate that has the right moisture level to support mushroom growth without becoming too wet or dry.